Vol. 7, Issue 1, Part B (2025)

Platelet-rich plasma (PRP) therapy has emerged a promising biological treatment for enhancing tendon and ligament healing offering a minimally invasive approach to tissue regeneration PRP is an autologous blood product that concentrates platelets and growth factors. Which are critical for tissue repair and regeneration, this review aims to comprehensively evaluate the efficacy of PRP therapy in promoting tendon and ligament repair highlighting its mechanisms of action clinical applications limitations and future directions. The methodology involved a systematic search of recent clinical trials meta-analyses and experimental studies published in peer-reviewed journals, Data extraction focused on key outcomes such as pain reduction, functional recovery and structural improvement in injured tissues,` Additionally variations in PRP preparation protocols and their impact on therapeutic outcomes were analyzed.
The result demonstrate` that PRP therapy significantly reduces pain, with Visual Analog Scale (VAS) scores decreasing from 7.2±1.3 at baseline to 1.9±0.7 at six months post-treatment (p<0.001) Functional recovery metrics, including Disabilities of the Arm Shoulder `and Hand (DASH) and Victorian Institute of Sport Assessment (VISA) scores also showed marked improvements. Structural evaluations using ultrasound and MRI revealed reduced tendon thickness, improved echogenicity increased collagen organization, and enhanced angiogenesis `These findings are supported by five detailed tables summarizing growth factor functions clinical study results, comparative analyses limitations, and meta-analysis data, along with 20 scientific citations
Despite ` potential challenges such as variability in preparation protocols lack of standardization, and high costs remain barriers to widespread adoption Variations in platelet concentration and dosing protocols contribute to inconsistent outcomes across studies underscoring the need for standardized guidelines Furthermore the economic burden of PRP therapy limits accessibility, particularly in resource-constrained settings.
This Results concludes that PRP therapy holds significant promise for accelerating healing and improving patient outcomes in tendon and ligament injuries. However further research is needed to optimize PRP preparation and administration protocols establish evidence-based guidelines, and address cost-effectiveness concerns by integrating insights from recent clinical trials meta-analyses and experimental studies this review provides a comprehensive evaluation of PRP therapy's current status and future potential in regenerative medicine.